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Mapping aggregation-specific interactions in human disease. The significance of protein misfolding and aggregation on the development of human disease is often underestimated and its consequences poorly understood. Only a few dozen aggregation-associated diseases have been identified, mostly neurodegenerative disorders or systemic amyloidoses. Neurodegenerative diseases are associated with a cytotoxic gain-of-function phenotype facilitating the incrimination of pr.
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